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There is a rare effect on the nerves and muscles with long-term use of colchicine, and a blood test from the muscle (CPK) is monitored at approximately six-month intervals in patients taking colchicine on a regular basis

That durability is why the same compound appears in both systemic and gut-local research models

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doi: 10.1016/j.immuni.2020.04.009 183 TeijeiraAGarasaSGatoMAlfaroCMiguelizICirellaAet al